Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study
Identifieur interne : 000496 ( Main/Exploration ); précédent : 000495; suivant : 000497Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study
Auteurs : Nicoletta De Rosa [Italie] ; Giada Lavitola [Italie] ; Pierluigi Giampaolino [Italie] ; Ilaria Morra [Italie] ; Carmine Nappi [Italie] ; Giuseppe Bifulco [Italie]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Abstract
Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF.
Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study. Patient underwent 6 months of therapy. At baseline and after 6 months all subjects performed Vaginal Health Index (VHI). The SF and QoL were measured by The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) and the Cervical Cancer Module (CXC-24).
After treatment a significant improvement of each parameter of VHI has been demonstrated. Global health status and emotional and social functioning scores improved significantly. On the contrary, general symptoms scales did not show significant difference from baseline data. Sexual activity, sexual vaginal functioning, body image, and sexual enjoyment scores increased significantly.
Ospemifene seems to be effective in decreasing the VVA symptoms in CC survivors.
Url:
DOI: 10.1155/2017/7513610
PubMed: 28781968
PubMed Central: 5525090
Affiliations:
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xml:lang="fr">Italie</country><wicri:regionArea>Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Lavitola, Giada" sort="Lavitola, Giada" uniqKey="Lavitola G" first="Giada" last="Lavitola">Giada Lavitola</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Giampaolino, Pierluigi" sort="Giampaolino, Pierluigi" uniqKey="Giampaolino P" first="Pierluigi" last="Giampaolino">Pierluigi Giampaolino</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Morra, Ilaria" sort="Morra, Ilaria" uniqKey="Morra I" first="Ilaria" last="Morra">Ilaria Morra</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Nappi, Carmine" sort="Nappi, Carmine" uniqKey="Nappi C" first="Carmine" last="Nappi">Carmine Nappi</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Public Health, University of Naples “Federico II”, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Public Health, University of Naples “Federico II”, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Bifulco, Giuseppe" sort="Bifulco, Giuseppe" uniqKey="Bifulco G" first="Giuseppe" last="Bifulco">Giuseppe Bifulco</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Obstetrics, Gynecology, and Urology, University of Naples “Federico II”, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p> Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF.</p></sec><sec><title> Materials and Methods</title><p> Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study. Patient underwent 6 months of therapy. At baseline and after 6 months all subjects performed Vaginal Health Index (VHI). The SF and QoL were measured by The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) and the Cervical Cancer Module (CXC-24).</p></sec><sec><title> Results</title><p> After treatment a significant improvement of each parameter of VHI has been demonstrated. Global health status and emotional and social functioning scores improved significantly. On the contrary, general symptoms scales did not show significant difference from baseline data. Sexual activity, sexual vaginal functioning, body image, and sexual enjoyment scores increased significantly.</p></sec><sec><title> Conclusion</title><p> Ospemifene seems to be effective in decreasing the VVA symptoms in CC survivors.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Froeding, L P" uniqKey="Froeding L">L. P. Froeding</name></author><author><name sortKey="Ottosen, C" uniqKey="Ottosen C">C. Ottosen</name></author><author><name sortKey="Rung Hansen, H" uniqKey="Rung Hansen H">H. Rung-Hansen</name></author><author><name sortKey="Svane, D" uniqKey="Svane D">D. Svane</name></author><author><name sortKey="Mosgaard, B J" uniqKey="Mosgaard B">B. J. Mosgaard</name></author><author><name sortKey="Jensen, P T" uniqKey="Jensen P">P. T. 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Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, S H" uniqKey="Chung S">S.-H. Chung</name></author><author><name sortKey="Lambert, P F" uniqKey="Lambert P">P. F. Lambert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="De Rosa, Nicoletta" sort="De Rosa, Nicoletta" uniqKey="De Rosa N" first="Nicoletta" last="De Rosa">Nicoletta De Rosa</name></noRegion><name sortKey="Bifulco, Giuseppe" sort="Bifulco, Giuseppe" uniqKey="Bifulco G" first="Giuseppe" last="Bifulco">Giuseppe Bifulco</name><name sortKey="Giampaolino, Pierluigi" sort="Giampaolino, Pierluigi" uniqKey="Giampaolino P" first="Pierluigi" last="Giampaolino">Pierluigi Giampaolino</name><name sortKey="Lavitola, Giada" sort="Lavitola, Giada" uniqKey="Lavitola G" first="Giada" last="Lavitola">Giada Lavitola</name><name sortKey="Morra, Ilaria" sort="Morra, Ilaria" uniqKey="Morra I" first="Ilaria" last="Morra">Ilaria Morra</name><name sortKey="Nappi, Carmine" sort="Nappi, Carmine" uniqKey="Nappi C" first="Carmine" last="Nappi">Carmine Nappi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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